This session at the Mental Health World Conference (MHWC 2026) will examine the latest advancements in the multimodal treatment, clinical classification, and diagnosis of mood disorders across the lifespan. International experts will gather for this session to discuss new biomarkers, advances in pharmacologic and psychotherapies, and subtleties in diagnosis. Particular attention will be paid to evidence-based practices, new therapies for refractory depression, digital tool monitoring, and care modalities that are culturally sensitive. Practical information on improving outcomes for a variety of populations, such as adolescents, older adults, and people with comorbid disorders, will be given to participants.